Immunomodulatory, antioxidant and antimicrobial activities of Gazania linearis: Correlation with its phytochemical profile
DOI:
https://doi.org/10.65406/3.1/32-37/2026Keywords:
Gazania linearis, Phytochemical screening, antimicrobial activity, Antioxidant activity, Oxidative burst assayAbstract
Gazania linearis is an ornamental plant native to South Africa, occasionally cultivated in Pakistan as a garden plant. The phytochemical screening on the plant indicated the presence of cardiac glycosides, anthraquinones, saponins, flavonoids and tannins. The dichloromethane plant extract (GLWPD) employed highest TPC contents; 273.79±1.32 while methanolic extract (GLWPM) moderately retained TFC contents; 74.11±0.89. The plant extract: GLWPD displayed the promising antimicrobial activity against a bacterial strain named Pseudomonas aeruginosa with 74.50% inhibition and a fungal strain named Microsporum canis with 72.80% inhibition. Both GLWPD and GLWPM extracts showed a significant antioxidant potential against DPPH with 61.07±0.12% and 80.34±2.10% inhibition at IC50 values; 53.10±1.71 and 40.38±2.53µg/mL respectively. GLWPM also indicated a notable immunomodulatory activity in oxidative burst assay with 71.3% ROS inhibition at IC50 value of 22.0±0.3µg/mL after comparison with the standard drug: ibuprofen. From this study, Gazania linearis is proved to have considerable antimicrobial, antioxidant and immunomodulatory properties due to the presence of medicinally active secondary metabolites.
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