Revolutionizing Oral Care: Diclofenac Sodium and Zinc Sulfate-Loaded Lozenges for Targeted Local Delivery for the Management of Oral Ulcers and Soft Tissue Lesions
DOI:
https://doi.org/10.65406/2.2/25-32/2025Keywords:
Oral ulcers, Soft tissue lesions, Localized drug delivery, Diclofenac sodium, Zinc sulphate, Pain management, Wound healingAbstract
Soft lozenges were developed as distinctive localized drug delivery system for managing oral ulcers along with soft tissue lesions. Prepared formulations incorporated drugs including diclofenac sodium for analgesic and anti-inflammatory effects, zinc sulfate for epithelial repair and menthol for soothing action in buccal cavity. Lozenges were prepared with methyl cellulose and PEG 6000 through molding technique. Comprehensive characterization included FTIR analysis, physicochemical evaluation such as hardness, surface pH, weight variation, friability and in vitro dissolution studies. First-order release kinetics with Fickian diffusion was revealed through drug release kinetics evaluation whereas FTIR study validated absence of interactions. These findings suggest that these lozenges offer a patient-friendly effective approach for localized oral therapy.
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